All You Would Want To Know About Semaglutide
Semaglutide is a medication belonging to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs).
It imitates the action of the GLP-1 hormone, which is naturally released in the gut after meals. Its primary function is to stimulate the production of insulin in the body, leading to a decrease in blood sugar levels. For more than 15 years, healthcare professionals have used semaglutide treatment for weight loss or treat Type 2 diabetes.
However, in addition to its role in diabetes management, GLP-1 in higher concentrations also affects the brain’s areas responsible for appetite regulation and satiety signals. When combined with a proper diet and exercise regimen, semaglutide has shown promising results in promoting significant weight loss. This weight loss can also lead to a reduced risk of conditions such as cancer, diabetes, and heart disease, particularly in individuals who are overweight or obese.
For weight loss purposes, semaglutide is currently available under the brand name Wegovy, Ozempic and Rybelsus. It is administered as weekly subcutaneous injections (under the skin).
Semaglutide has demonstrated remarkable effectiveness in promoting weight loss in non-diabetic individuals. In a study involving 2,000 obese adults, those using semaglutide alongside a diet and exercise program achieved substantial results. After 68 weeks, half of the participants using semaglutide lost 15% of their body weight, and nearly a third lost 20%, whereas those who only made lifestyle changes lost approximately 2.4% of their weight.
However, it’s important to note that weight regain can occur when individuals discontinue the use of semaglutide.
SIDE EFFECTS:
Semaglutide typically causes mild side effects compared to the complications associated with obesity. Common side effects include dizziness, fatigue, gastrointestinal issues (such as diarrhea, constipation, and gas), headaches, and stomach discomfort (nausea, vomiting, pain, or bloating). These side effects can often be mitigated by starting with a lower dose and gradually increasing it.
AM I A GOOD CANDIDATE FOR SEMAGLUTIDE?
The FDA recommends semaglutide for weight loss if you have a body mass index (BMI) of 27kg/m² or greater and at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol) or a BMI of 30kg/m² or greater. However, individuals with a history of certain conditions, such as medullary thyroid cancer, gallbladder disease, pancreatitis, or multiple endocrine neoplasia syndrome type 2 (MEN2), should avoid using semaglutide for weight loss.
Before considering semaglutide injection for non diabetics, it is crucial to consult a physician to discuss your medical history and determine the best treatment approach for your specific situation. If you already have diabetes and are taking other medications, consult with your physician to ensure safe and appropriate combinations of diabetes medications.
