Botox vs Dysport vs Xeomin vs Daxxify: 4 Alternatives for Anti-aging Injectables
Botox has practically become synonymous with smoothing out wrinkles and achieving that youthful, refreshed look we all crave. But Botox isn’t the only drug. There’s a whole family of injectable treatments other than Botox, all designed to help you achieve anti-aging. Some of these that exist in the market: Dysport, Xeomin, and Daxxify.
Botox, along with its alternatives, belongs to a group of drugs called neuromodulators. In simple terms, these are substances derived from a purified form of botulinum toxin.
If you’re wondering, “If they all do basically the same thing, does it matter which one I choose?” That’s what we are going to talk more about. Each of these injectables has its own unique characteristics. Some might work faster, others might last longer, and some might be better suited for certain areas.
In this Blog:
- We’re going to break down the differences between Botox, Dysport, Xeomin, and Daxxify.
- We’re going to look at how they work, what makes each one special, and help you understand which might be the best fit for you.
Understanding Neuromodulators
Before getting into the specifics of each drug, it’s essential to understand what neuromodulators are and how they work. Neuromodulators are injectable substances that temporarily block nerve signals to muscles, causing them to relax. In the context of cosmetic treatments, this relaxation helps to reduce the appearance of wrinkles and fine lines that are caused by repetitive muscle movements, such as frowning or squinting.
The active ingredients in these drugs are derived from botulinum toxin type A, a naturally occurring protein produced by the bacterium Clostridium botulinum. When injected in small, controlled doses, these neuromodulators effectively smooth out wrinkles and prevent new ones from forming, all while maintaining natural facial expressions.
Let’s understand each of these drugs one by one.
Botox
Botox, short for Botulinum Toxin, was the first neuromodulator to receive FDA approval for cosmetic use in 2002. Its active ingredient, OnabotulinumtoxinA, has been used for decades in both medical and aesthetic applications. Botox is most commonly used to treat:
- Forehead lines
- Frown lines between the eyebrows (glabellar lines)
- Crow’s feet around the eyes
- Bunny lines on the nose
The effects of Botox typically last 3-4 months, though this can vary depending on the individual and the treatment area. Its long-standing presence in the market has made it the most recognized brand among neuromodulators, often used as a generic term for all botulinum toxin treatments.
Dysport
Dysport (AbobotulinumtoxinA) entered the U.S. market in 2009, offering an alternative to Botox. While it functions similarly, Dysport has some unique characteristics:
- It tends to diffuse more, spreading to a wider area after injection
- Many patients report a faster onset of action, often seeing results within 2-3 days
- Its effects may last slightly longer than Botox in some cases
Dysport is particularly effective for treating larger areas, such as forehead lines, due to its spreading properties. However, this also means it requires precise injection technique to avoid affecting unintended muscles.
Xeomin
Approved by the FDA in 2010, Xeomin (IncobotulinumtoxinA) is often referred to as the “naked” injectable because it contains only the pure form of botulinum toxin A, without any additives or complexing proteins (not to be confused with complex proteins). This unique characteristic offers several potential benefits:
- Reduced risk of developing antibodies that could make the treatment less effective over time
- Possibility of being a better option for patients who have developed resistance to other neuromodulators
Xeomin’s effects typically last 3-4 months, similar to Botox. It’s particularly popular for treating frown lines between the eyebrows, though it’s used in other areas as well, similar to Botox.
Daxxify
The newest addition to the neuromodulator family, Daxxify (DaxibotulinumtoxinA), received FDA approval in September 2022. What sets Daxxify apart is its innovative peptide technology, which allows for longer-lasting results. Key features include:
- Effects lasting up to 6-9 months in clinical trials, significantly longer than other neuromodulators
- A unique stabilizing peptide that enhances its binding to nerve cells
- Potential for fewer treatments per year, which could be more convenient for patients
While Daxxify is still relatively new to the market, its extended duration of action has generated significant interest in the aesthetic community.
Comparing the Four Neuromodulators
While all four neuromodulators function similarly at a basic level, there are some key differences to consider:
- Onset of Action:
- Dysport often shows the fastest results, with effects noticeable within 2-3 days
- Botox and Xeomin typically take 3-5 days to show effects
- Daxxify’s onset is similar to Botox and Xeomin
- Duration of Effects:
- Daxxify leads the pack with effects lasting up to 6-9 months
- Botox, Dysport, and Xeomin typically last 3-4 months, though individual results may vary
- Spread (Diffusion):
- Dysport tends to diffuse more widely, which can be beneficial for larger treatment areas
- Botox, Xeomin, and Daxxify have more localized effects
- Potential for Antibody Formation:
- Xeomin, being a “pure” form of the toxin, may have a lower risk of antibody formation
- The other products contain complexing proteins, which could potentially lead to antibody development in some patients over time.
Feature | Botox | Dysport | Xeomin | Daxxify |
Active Ingredient | OnabotulinumtoxinA | AbobotulinumtoxinA | IncobotulinumtoxinA | DaxibotulinumtoxinA |
Onset of Action | 3-5 days | 2-3 days | 3-5 days | 3-5 days |
Duration of Effects | 3-4 months | 3-4 months | 3-4 months | 6-9 months |
Spread/Diffusion | Moderate | Higher | Moderate | Higher |
Complexing Proteins | Yes | Yes | No (Naked injectable) | Yes (with peptide technology) |
Best For | Versatile, good for most areas | Larger areas (e.g., forehead) | Patients with Botox resistance | Long-lasting results |
Unique Feature | Most well-known brand | Fast onset | Pure form, may reduce antibody formation | Longest-lasting effects |
Cost | $$$ | $$ | $$ | $$$$ |
Ideal For | First-time users, those happy with previous Botox results | Those wanting quicker results, larger treatment areas | Those who’ve developed resistance to other neuromodulators | Those seeking less frequent treatments |
Which One Should You Choose?
Selecting the right neuromodulator depends on various factors:
- Individual Needs: Consider your specific concerns and desired outcomes. For example, if you’re looking for the longest-lasting results, Daxxify might be appealing.
- Treatment Area: The size and location of the area being treated can influence the choice. Dysport’s diffusion properties might make it ideal for larger areas like the forehead.
- Personal Response: Some individuals may respond better to one product over another. Your practitioner might recommend trying different options to find the best fit.
- Cost Considerations: While prices can vary, newer products like Daxxify may be more expensive. However, the extended duration could mean fewer treatments per year.
- Practitioner Recommendation: An experienced healthcare provider can assess your unique facial anatomy and recommend the most suitable product.
Safety Considerations and Side Effects
All four neuromodulators have similar safety profiles and potential side effects, which can include:
- Temporary bruising or swelling at the injection site
- Headache
- Drooping eyelids or eyebrows (if injected improperly)
- Asymmetry or an unnatural “frozen” look (usually due to overtreatment)
Hence, it’s crucial to choose a qualified, experienced practitioner to minimize the risk of side effects and ensure optimal results.
Conclusion
While Botox remains the most recognized name, Dysport, Xeomin, and Daxxify each bring unique benefits to the table. Whether you’re looking for fast-acting results, reduced risk of antibody formation, or long-lasting effects, there’s likely a neuromodulator that fits your needs.
As with any cosmetic treatment, the key to finding the right fit lies in consultation with a knowledgeable healthcare professional. They can assess your individual needs, explain the nuances of each product, and help you make an informed decision about which neuromodulator is right for you.
Book a call with us today to find out your best fit. Booking a consultation with us today!
- Are these neuromodulators safe?
Yes, when administered by a qualified professional, all four products are considered safe and have undergone rigorous clinical trials.
- How long do the effects last?
Effects typically last 3-4 months for Botox, Dysport, and Xeomin. Daxxify can last up to 6-9 months.
- Will I look “frozen” after treatment?
A skilled practitioner will aim for a natural look that preserves facial expressions. The “frozen” look is typically a result of overtreatment.
- Can I switch between different neuromodulators?
Yes, it’s possible to switch between products. Your healthcare provider can guide you on the best approach.
- Are there any age restrictions for these treatments?
While there’s no strict age limit, most practitioners recommend starting treatment when fine lines begin to appear, typically in the late 20s or early 30s.